Assay Detail
Binding
CHEMBL4042011
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATP
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Natural-Based Indirubins Display Potent Cytotoxicity toward Wild-Type and T315I-Resistant Leukemia Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.74 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495306 | — | — | 1 | 9.21 |
| CHEMBL493657 | — | — | 1 | 9.08 |
| CHEMBL493656 | — | — | 1 | 8.77 |
| CHEMBL493883 | — | — | 1 | 8.66 |
| CHEMBL3215571 | — | — | 1 | 8.41 |
| CHEMBL494685 | — | — | 1 | 8.31 |
| CHEMBL494867 | — | — | 1 | - |
| CHEMBL3216659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495306 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL493657 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL493656 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL493883 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3215571 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL494685 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL494867 | — | IC50 | < | 0.5 | nM | - |
| CHEMBL3216659 | — | IC50 | < | 0.5 | nM | - |