Assay Detail
Binding
CHEMBL4042014
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Activation of PKC in human platelet assessed as induction of platelet aggregation measured within 15 mins by tribidimetric method
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Isolation of Phorbol Esters from Euphorbia grandicornis and Evaluation of Protein Kinase C- and Human Platelet-Activating Effects of Euphorbiaceae Diterpenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.34 | 8.02 |
| Activity | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | 2.0 | 2 | 8.02 |
| CHEMBL1863513 | INGENOL MEBUTATE | 4.0 | 2 | 7.14 |
| CHEMBL170518 | PROSTRATIN | — | 2 | 6.04 |
| CHEMBL4071723 | — | — | 2 | 5.30 |
| CHEMBL4104319 | — | — | 2 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL1863513 | INGENOL MEBUTATE | EC50 | = | 72.5 | nM | 7.14 |
| CHEMBL170518 | PROSTRATIN | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4071723 | — | EC50 | = | 5040.0 | nM | 5.30 |
| CHEMBL4104319 | — | EC50 | = | 6080.0 | nM | 5.22 |
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | Activity | - | — | - | |
| CHEMBL170518 | PROSTRATIN | Activity | - | — | - | |
| CHEMBL1863513 | INGENOL MEBUTATE | Activity | - | — | - | |
| CHEMBL4071723 | — | Activity | - | — | - | |
| CHEMBL4104319 | — | Activity | - | — | - |