Assay Detail
Binding
CHEMBL4042091
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAO-B assessed as reduction in 4-hydroxyquinolone production using kynuramine as substrate after 20 mins by fluorescence assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.19 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4068321 | — | — | 1 | 9.30 |
| CHEMBL4079843 | — | — | 1 | 9.10 |
| CHEMBL4097867 | — | — | 1 | 9.05 |
| CHEMBL4105601 | — | — | 1 | 8.89 |
| CHEMBL4095676 | — | — | 1 | 8.72 |
| CHEMBL108660 | — | — | 1 | 8.70 |
| CHEMBL4094745 | — | — | 1 | 8.68 |
| CHEMBL4082300 | — | — | 1 | 8.66 |
| CHEMBL145781 | 7-BENZYLOXYCOUMARIN | — | 1 | 8.42 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 8.10 |
| CHEMBL4060398 | — | — | 1 | 7.89 |
| CHEMBL4069084 | — | — | 1 | 7.75 |
| CHEMBL4090150 | — | — | 1 | 7.14 |
| CHEMBL4087723 | — | — | 1 | 6.98 |
| CHEMBL4067432 | — | — | 1 | 6.54 |
| CHEMBL4088674 | — | — | 1 | 6.52 |
| CHEMBL4078343 | — | — | 1 | 6.33 |
| CHEMBL4096387 | — | — | 1 | 6.28 |
| CHEMBL4089608 | — | — | 1 | 5.85 |
| CHEMBL4104128 | — | — | 1 | 5.81 |
| CHEMBL4066437 | — | — | 1 | 5.77 |
| CHEMBL4091054 | — | — | 1 | 5.51 |
| CHEMBL4086218 | — | — | 1 | 5.44 |
| CHEMBL4093982 | — | — | 1 | 5.27 |
| CHEMBL4061479 | — | — | 1 | 5.25 |
| CHEMBL4063174 | — | — | 1 | 5.04 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
| CHEMBL95 | TACRINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4068321 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4079843 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4097867 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4105601 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4095676 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL108660 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4094745 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4082300 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL145781 | 7-BENZYLOXYCOUMARIN | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL972 | SELEGILINE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4060398 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4069084 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4090150 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4087723 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4067432 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4088674 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4078343 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4096387 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4089608 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4104128 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4066437 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4091054 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL4086218 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4093982 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL4061479 | — | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL4063174 | — | IC50 | = | 9210.0 | nM | 5.04 |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - | |
| CHEMBL502 | DONEPEZIL | IC50 | - | — | - | |
| CHEMBL95 | TACRINE | IC50 | - | — | - |