Assay Detail
Functional
CHEMBL4042129
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Cytotoxicity against human KB/S cells assessed as reduction in cell viability after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB/S |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A Hexacyclic, Iboga-Derived Monoterpenoid Indole with a Contracted Tetrahydroazepine C-Ring and Incorporation of an Isoxazolidine Moiety, a Seco-Corynanthean, an Aspidosperma-Aspidosperma Bisindole with Anticancer Properties, and the Absolute Configuration of the Pyridopyrimidine Indole Alkaloid, Vernavosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.94 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.70 |
| CHEMBL4087281 | — | — | 1 | 6.30 |
| CHEMBL220132 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4087281 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL220132 | — | IC50 | = | 1500.0 | nM | 5.82 |