Assay Detail
Functional
CHEMBL4042258
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Cytotoxicity against human A549 cells assessed as growth inhibition by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (LSD1/KDM1A) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.87 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4091439 | — | — | 1 | 5.06 |
| CHEMBL4087815 | — | — | 1 | 5.05 |
| CHEMBL4069335 | — | — | 1 | 5.05 |
| CHEMBL2177862 | — | — | 1 | 5.01 |
| CHEMBL4070519 | — | — | 1 | 5.00 |
| CHEMBL4089024 | — | — | 1 | 4.99 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.86 |
| CHEMBL4099168 | — | — | 1 | 4.86 |
| CHEMBL4067124 | — | — | 1 | 4.79 |
| CHEMBL4080060 | — | — | 1 | 4.79 |
| CHEMBL4060712 | — | — | 1 | 4.77 |
| CHEMBL4083660 | — | — | 1 | 4.76 |
| CHEMBL4060820 | — | — | 1 | 4.75 |
| CHEMBL4061895 | — | — | 1 | 4.70 |
| CHEMBL4101839 | — | — | 1 | 4.64 |
| CHEMBL4099019 | — | — | 1 | - |
| CHEMBL3786182 | GSK2879552 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4091439 | — | IC50 | = | 8790.0 | nM | 5.06 |
| CHEMBL4087815 | — | IC50 | = | 8870.0 | nM | 5.05 |
| CHEMBL4069335 | — | IC50 | = | 8850.0 | nM | 5.05 |
| CHEMBL2177862 | — | IC50 | = | 9740.0 | nM | 5.01 |
| CHEMBL4070519 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4089024 | — | IC50 | = | 10340.0 | nM | 4.99 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 13950.0 | nM | 4.86 |
| CHEMBL4099168 | — | IC50 | = | 13880.0 | nM | 4.86 |
| CHEMBL4067124 | — | IC50 | = | 16410.0 | nM | 4.79 |
| CHEMBL4080060 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL4060712 | — | IC50 | = | 17030.0 | nM | 4.77 |
| CHEMBL4083660 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL4060820 | — | IC50 | = | 17960.0 | nM | 4.75 |
| CHEMBL4061895 | — | IC50 | = | 19770.0 | nM | 4.70 |
| CHEMBL4101839 | — | IC50 | = | 22760.0 | nM | 4.64 |
| CHEMBL4099019 | — | IC50 | - | — | - | |
| CHEMBL3786182 | GSK2879552 | IC50 | - | — | - |