Assay Detail
Binding
CHEMBL4042319
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Inhibition of hedgehog signaling pathway in mouse NIH/3T3 cells measured after 24 hrs by Gli-dual luciferase reporter gene assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of structurally modified isoindolinone and quinazolinone derivatives as hedgehog pathway inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.12 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 8.30 |
| CHEMBL2105737 | SONIDEGIB | 4.0 | 1 | 8.22 |
| CHEMBL4085192 | — | — | 1 | 7.42 |
| CHEMBL4062516 | — | — | 1 | 6.93 |
| CHEMBL4069342 | — | — | 1 | 6.88 |
| CHEMBL4065264 | — | — | 1 | 6.80 |
| CHEMBL4066003 | — | — | 1 | 6.71 |
| CHEMBL4100661 | — | — | 1 | 6.71 |
| CHEMBL4092196 | — | — | 1 | 6.57 |
| CHEMBL4073883 | — | — | 1 | 6.52 |
| CHEMBL4084220 | — | — | 1 | 6.37 |
| CHEMBL4067971 | — | — | 1 | 6.36 |
| CHEMBL4095372 | — | — | 1 | 6.36 |
| CHEMBL4071118 | — | — | 1 | 6.07 |
| CHEMBL4083498 | — | — | 1 | 5.94 |
| CHEMBL4096574 | — | — | 1 | 5.91 |
| CHEMBL4061697 | — | — | 1 | 5.77 |
| CHEMBL4104858 | — | — | 1 | 5.75 |
| CHEMBL4074940 | — | — | 1 | 5.34 |
| CHEMBL4061338 | — | — | 1 | 5.28 |
| CHEMBL4103126 | — | — | 1 | 5.27 |
| CHEMBL4093727 | — | — | 1 | 5.18 |
| CHEMBL4073077 | — | — | 1 | 5.13 |
| CHEMBL4066294 | — | — | 1 | 5.11 |
| CHEMBL4086990 | — | — | 1 | 5.11 |
| CHEMBL4068100 | — | — | 1 | 4.82 |
| CHEMBL4102587 | — | — | 1 | 4.36 |
| CHEMBL4064497 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473417 | VISMODEGIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2105737 | SONIDEGIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4085192 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4062516 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL4069342 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL4065264 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL4066003 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL4100661 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL4092196 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL4073883 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL4084220 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4067971 | — | IC50 | = | 439.0 | nM | 6.36 |
| CHEMBL4095372 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL4071118 | — | IC50 | = | 847.0 | nM | 6.07 |
| CHEMBL4083498 | — | IC50 | = | 1142.0 | nM | 5.94 |
| CHEMBL4096574 | — | IC50 | = | 1237.0 | nM | 5.91 |
| CHEMBL4061697 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4104858 | — | IC50 | = | 1796.0 | nM | 5.75 |
| CHEMBL4074940 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL4061338 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL4103126 | — | IC50 | = | 5410.0 | nM | 5.27 |
| CHEMBL4093727 | — | IC50 | = | 6603.0 | nM | 5.18 |
| CHEMBL4073077 | — | IC50 | = | 7489.0 | nM | 5.13 |
| CHEMBL4066294 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4086990 | — | IC50 | = | 7692.0 | nM | 5.11 |
| CHEMBL4068100 | — | IC50 | = | 15260.0 | nM | 4.82 |
| CHEMBL4102587 | — | IC50 | = | 44200.0 | nM | 4.36 |
| CHEMBL4064497 | — | IC50 | > | 20000.0 | nM | - |