Assay Detail
Binding
CHEMBL4042328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hedgehog signaling pathway in mouse NIH/3T3 cells expressing wild type Smo assessed as reduction in Gli mRNA expression by RT-PCR method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of structurally modified isoindolinone and quinazolinone derivatives as hedgehog pathway inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.43 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105737 | SONIDEGIB | 4.0 | 1 | 8.36 |
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 7.84 |
| CHEMBL4062516 | — | — | 1 | 6.94 |
| CHEMBL4085192 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105737 | SONIDEGIB | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL473417 | VISMODEGIB | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL4062516 | — | IC50 | = | 113.7 | nM | 6.94 |
| CHEMBL4085192 | — | IC50 | = | 256.6 | nM | 6.59 |