Assay Detail
Functional
CHEMBL4042365
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV genotype 1b infected in human HuH5.2 cells with persistent I389luc-ubi-neo/NS3-3'/5.1 replicon after 72 hrs by luciferase reporter gene assay
101
Total Activities
68
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 68 | 4.87 | 6.10 |
| EC90 | 33 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.10 |
| CHEMBL4073039 | — | — | 1 | 5.92 |
| CHEMBL4066868 | — | — | 2 | 5.89 |
| CHEMBL4078074 | — | — | 1 | 5.77 |
| CHEMBL4103386 | — | — | 1 | 5.70 |
| CHEMBL4059548 | — | — | 1 | 5.67 |
| CHEMBL4075921 | — | — | 2 | 5.66 |
| CHEMBL4086891 | — | — | 1 | 5.52 |
| CHEMBL4076316 | — | — | 2 | 5.46 |
| CHEMBL4082636 | — | — | 1 | 5.43 |
| CHEMBL4104767 | — | — | 1 | 5.42 |
| CHEMBL4093709 | — | — | 1 | 5.40 |
| CHEMBL4063334 | — | — | 1 | 5.31 |
| CHEMBL4072741 | — | — | 1 | 5.19 |
| CHEMBL4089207 | — | — | 2 | 5.18 |
| CHEMBL4085961 | — | — | 1 | 5.18 |
| CHEMBL4104740 | — | — | 2 | 5.06 |
| CHEMBL4102345 | — | — | 2 | 5.03 |
| CHEMBL4087121 | — | — | 2 | 5.00 |
| CHEMBL4091436 | — | — | 2 | 5.00 |
| CHEMBL4066918 | — | — | 1 | 4.98 |
| CHEMBL4076772 | — | — | 1 | 4.97 |
| CHEMBL4095027 | — | — | 1 | 4.92 |
| CHEMBL4073008 | — | — | 1 | 4.92 |
| CHEMBL4070921 | — | — | 1 | 4.92 |
| CHEMBL4095326 | — | — | 1 | 4.89 |
| CHEMBL590023 | — | — | 1 | 4.88 |
| CHEMBL4077120 | — | — | 1 | 4.76 |
| CHEMBL4076162 | — | — | 2 | 4.74 |
| CHEMBL4077147 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231813 | TELAPREVIR | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4073039 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4066868 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4078074 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4103386 | — | EC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4059548 | — | EC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL4075921 | — | EC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL4086891 | — | EC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL4076316 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4082636 | — | EC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL4104767 | — | EC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL4093709 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4063334 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4072741 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4089207 | — | EC50 | = | 6620.0 | nM | 5.18 |
| CHEMBL4085961 | — | EC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL4104740 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4102345 | — | EC50 | = | 9320.0 | nM | 5.03 |
| CHEMBL4087121 | — | EC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL4091436 | — | EC50 | = | 9930.0 | nM | 5.00 |
| CHEMBL4066918 | — | EC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4076772 | — | EC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4095027 | — | EC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL4070921 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4073008 | — | EC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL4095326 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL590023 | — | EC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL4077120 | — | EC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL4076162 | — | EC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4077147 | — | EC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL4067609 | — | EC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL4076613 | — | EC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL4076214 | — | EC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL1444743 | — | EC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL4078821 | — | EC50 | = | 35800.0 | nM | 4.45 |
| CHEMBL4075563 | — | EC50 | = | 39600.0 | nM | 4.40 |
| CHEMBL4086670 | — | EC50 | = | 41800.0 | nM | 4.38 |
| CHEMBL4068187 | — | EC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL4073174 | — | EC50 | = | 56200.0 | nM | 4.25 |
| CHEMBL4102358 | — | EC50 | = | 57200.0 | nM | 4.24 |
| CHEMBL4068770 | — | EC50 | = | 58300.0 | nM | 4.23 |
| CHEMBL4076373 | — | EC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL4097200 | — | EC50 | = | 61900.0 | nM | 4.21 |
| CHEMBL4094601 | — | EC50 | = | 64300.0 | nM | 4.19 |
| CHEMBL4077360 | — | EC50 | = | 66700.0 | nM | 4.18 |
| CHEMBL4064427 | — | EC50 | = | 69200.0 | nM | 4.16 |
| CHEMBL4076812 | — | EC50 | = | 76900.0 | nM | 4.11 |
| CHEMBL4087856 | — | EC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL4063262 | — | EC50 | = | 81700.0 | nM | 4.09 |
| CHEMBL4089629 | — | EC50 | = | 85800.0 | nM | 4.07 |