Assay Detail
Binding
CHEMBL4042370
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Inhibition of HCV NS3 helicase ATP hydrolysis activity in presence of poly(U) RNA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.68 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4066868 | — | — | 1 | 4.68 |
| CHEMBL4095326 | — | — | 1 | - |
| CHEMBL4104740 | — | — | 1 | - |
| CHEMBL4082513 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4066868 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4095326 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4104740 | — | IC50 | = | 590000.0 | nM | - |
| CHEMBL4082513 | — | IC50 | > | 1000000.0 | nM | - |