Assay Detail
Binding
CHEMBL4042623
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Inhibition of quorum sensing LasI synthase in Pseudomonas aeruginosa PAO1 harboring reporter plasmid lasB-gfp assessed as reduction in lasB expression measured every 15 mins for 12 hrs by GFP-fluorescence assay
34
Total Activities
30
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa PAO1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.45 | 6.25 |
| Inhibition | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4080882 | — | — | 1 | 6.25 |
| CHEMBL4066360 | — | — | 1 | 6.24 |
| CHEMBL4065077 | — | — | 1 | 6.17 |
| CHEMBL4069062 | — | — | 1 | 6.14 |
| CHEMBL4084472 | — | — | 1 | 6.11 |
| CHEMBL4098007 | — | — | 2 | 6.01 |
| CHEMBL4079124 | — | — | 1 | 5.95 |
| CHEMBL4105114 | — | — | 1 | 5.87 |
| CHEMBL4103368 | — | — | 1 | 5.87 |
| CHEMBL4084326 | — | — | 1 | 5.78 |
| CHEMBL4075222 | — | — | 2 | 5.67 |
| CHEMBL4062632 | — | — | 1 | 5.66 |
| CHEMBL4070229 | — | — | 2 | 5.64 |
| CHEMBL4077348 | — | — | 1 | 5.49 |
| CHEMBL4090410 | — | — | 1 | 5.46 |
| CHEMBL4102421 | — | — | 1 | 5.45 |
| CHEMBL4094674 | — | — | 1 | 5.39 |
| CHEMBL2315299 | — | — | 1 | 5.22 |
| CHEMBL4063268 | — | — | 1 | 4.92 |
| CHEMBL508112 | BENZOTHIAZYL DISULFIDE | — | 1 | 4.84 |
| CHEMBL122890 | AJOENE | — | 1 | 4.82 |
| CHEMBL4079822 | — | — | 1 | 4.77 |
| CHEMBL4074170 | — | — | 1 | 4.68 |
| CHEMBL4067519 | — | — | 1 | 4.51 |
| CHEMBL241149 | — | — | 2 | 4.44 |
| CHEMBL2398107 | — | — | 1 | 4.34 |
| CHEMBL4074916 | — | — | 1 | - |
| CHEMBL4076132 | — | — | 1 | - |
| CHEMBL4080541 | — | — | 1 | - |
| CHEMBL4073101 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4080882 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4066360 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4065077 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4069062 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4084472 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4098007 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4079124 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4105114 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4103368 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4084326 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4075222 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL4062632 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4070229 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL4077348 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL4090410 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL4102421 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL4094674 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL2315299 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4063268 | — | IC50 | = | 12130.0 | nM | 4.92 |
| CHEMBL508112 | BENZOTHIAZYL DISULFIDE | IC50 | = | 14480.0 | nM | 4.84 |
| CHEMBL122890 | AJOENE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4079822 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL4074170 | — | IC50 | = | 20920.0 | nM | 4.68 |
| CHEMBL4067519 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL241149 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL2398107 | — | IC50 | = | 45380.0 | nM | 4.34 |
| CHEMBL4075222 | — | Inhibition | - | % | - | |
| CHEMBL241149 | — | Inhibition | - | % | - | |
| CHEMBL4098007 | — | Inhibition | - | % | - | |
| CHEMBL4070229 | — | Inhibition | - | % | - | |
| CHEMBL4073101 | — | Inhibition | - | % | - | |
| CHEMBL4080541 | — | Inhibition | - | % | - | |
| CHEMBL4076132 | — | Inhibition | - | % | - | |
| CHEMBL4074916 | — | Inhibition | - | % | - |