Assay Detail
Functional
CHEMBL4042869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human HepG2 cells after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Solvent free, catalyst free, microwave or grinding assisted synthesis of bis-cyclic imide derivatives and their evaluation for anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.60 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097759 | — | — | 1 | 4.91 |
| CHEMBL4103728 | — | — | 1 | 4.77 |
| CHEMBL4079481 | — | — | 1 | 4.76 |
| CHEMBL4060286 | — | — | 1 | 4.74 |
| CHEMBL4070620 | — | — | 1 | 4.62 |
| CHEMBL4083886 | — | — | 1 | 4.56 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.48 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | 4.0 | 1 | 4.28 |
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097759 | — | IC50 | = | 12410.0 | nM | 4.91 |
| CHEMBL4103728 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4079481 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4060286 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL4070620 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL4083886 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 32870.0 | nM | 4.48 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | IC50 | = | 52300.0 | nM | 4.28 |
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 55120.0 | nM | 4.26 |