Assay Detail
Functional
CHEMBL4042907
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Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological activities of tetrandrine and fangchinoline derivatives as antitumer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.42 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4104371 | — | — | 1 | 6.26 |
| CHEMBL4075811 | — | — | 1 | 6.19 |
| CHEMBL4069987 | — | — | 1 | 5.88 |
| CHEMBL4068710 | — | — | 1 | 5.77 |
| CHEMBL4077081 | — | — | 1 | 5.75 |
| CHEMBL4081598 | — | — | 1 | 5.70 |
| CHEMBL4089477 | — | — | 1 | 5.70 |
| CHEMBL4097179 | — | — | 1 | 5.68 |
| CHEMBL4061313 | — | — | 1 | 5.67 |
| CHEMBL4099602 | — | — | 1 | 5.55 |
| CHEMBL4095281 | — | — | 1 | 5.53 |
| CHEMBL4105207 | — | — | 1 | 5.45 |
| CHEMBL4062143 | — | — | 1 | 5.43 |
| CHEMBL4077545 | — | — | 1 | 5.42 |
| CHEMBL4082088 | — | — | 1 | 5.41 |
| CHEMBL4100856 | — | — | 1 | 5.40 |
| CHEMBL4096483 | — | — | 1 | 5.38 |
| CHEMBL4077981 | — | — | 1 | 5.31 |
| CHEMBL4076675 | — | — | 1 | 5.28 |
| CHEMBL4096026 | — | — | 1 | 5.26 |
| CHEMBL176045 | FANCHININ | — | 1 | 5.17 |
| CHEMBL504256 | FANGCHINOLINE | — | 1 | 5.04 |
| CHEMBL4105566 | — | — | 1 | 5.01 |
| CHEMBL4076452 | — | — | 1 | 5.00 |
| CHEMBL4067023 | — | — | 1 | 5.00 |
| CHEMBL4080440 | — | — | 1 | 4.88 |
| CHEMBL4104667 | — | — | 1 | 4.80 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4104371 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4075811 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4069987 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4068710 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4077081 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4081598 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4089477 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4097179 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL4061313 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL4099602 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL4095281 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4105207 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL4062143 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL4077545 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL4082088 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL4100856 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4096483 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL4077981 | — | IC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL4076675 | — | IC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL4096026 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL176045 | FANCHININ | IC50 | = | 6820.0 | nM | 5.17 |
| CHEMBL504256 | FANGCHINOLINE | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL4105566 | — | IC50 | = | 9670.0 | nM | 5.01 |
| CHEMBL4076452 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4067023 | — | IC50 | = | 9980.0 | nM | 5.00 |
| CHEMBL4080440 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL4104667 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL535 | SUNITINIB | IC50 | = | 16060.0 | nM | 4.79 |