Assay Detail
Functional
CHEMBL4043481
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Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxic activities of goniothalamins and derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.24 | 4.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4076503 | — | — | 1 | 4.54 |
| CHEMBL4105023 | — | — | 1 | 4.32 |
| CHEMBL464443 | GONIOTHALAMIN | — | 1 | 4.26 |
| CHEMBL4070592 | — | — | 1 | 4.17 |
| CHEMBL4083205 | — | — | 1 | 4.12 |
| CHEMBL4102290 | — | — | 1 | 4.05 |
| CHEMBL4082163 | — | — | 1 | - |
| CHEMBL4100164 | — | — | 1 | - |
| CHEMBL4105461 | — | — | 1 | - |
| CHEMBL4081209 | — | — | 1 | - |
| CHEMBL4097738 | — | — | 1 | - |
| CHEMBL1240592 | — | — | 1 | - |
| CHEMBL4086396 | — | — | 1 | - |
| CHEMBL4080887 | — | — | 1 | - |
| CHEMBL4060533 | — | — | 1 | - |
| CHEMBL1170485 | — | — | 1 | - |
| CHEMBL4086595 | — | — | 1 | - |
| CHEMBL4090229 | — | — | 1 | - |
| CHEMBL4069823 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4076503 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL4105023 | — | IC50 | = | 48200.0 | nM | 4.32 |
| CHEMBL464443 | GONIOTHALAMIN | IC50 | = | 55500.0 | nM | 4.26 |
| CHEMBL4070592 | — | IC50 | = | 68300.0 | nM | 4.17 |
| CHEMBL4083205 | — | IC50 | = | 76200.0 | nM | 4.12 |
| CHEMBL4102290 | — | IC50 | = | 88700.0 | nM | 4.05 |
| CHEMBL4082163 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4100164 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4105461 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4081209 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4097738 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1240592 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4086396 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4080887 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4060533 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1170485 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4086595 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4090229 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4069823 | — | IC50 | > | 100000.0 | nM | - |