Assay Detail
Functional
CHEMBL4043792
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Antiproliferative activity against human FGFR2-amplified SUM52 cells after 5 days by SRB assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SUM52 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.70 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4060079 | — | — | 1 | 9.24 |
| CHEMBL4096041 | — | — | 1 | 9.19 |
| CHEMBL4069509 | — | — | 1 | 9.19 |
| CHEMBL4092508 | — | — | 1 | 9.11 |
| CHEMBL4100258 | — | — | 1 | 9.10 |
| CHEMBL4088313 | — | — | 1 | 9.08 |
| CHEMBL4068733 | — | — | 1 | 9.00 |
| CHEMBL4079538 | — | — | 1 | 8.96 |
| CHEMBL4103795 | — | — | 1 | 8.96 |
| CHEMBL4092354 | — | — | 1 | 8.70 |
| CHEMBL2216830 | — | — | 1 | 8.54 |
| CHEMBL4077029 | — | — | 1 | 8.48 |
| CHEMBL4096738 | — | — | 1 | 8.40 |
| CHEMBL189584 | PD-173074 | — | 1 | 7.91 |
| CHEMBL4084614 | — | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4060079 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL4096041 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL4069509 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL4092508 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL4100258 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4088313 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL4068733 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4079538 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4103795 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4092354 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2216830 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4077029 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4096738 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL189584 | PD-173074 | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL4084614 | — | IC50 | = | 224.0 | nM | 6.65 |