Assay Detail
Binding
CHEMBL4044325
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Inhibition of full-length recombinant human dCTPase at by microtiter plate-adapted malachite green assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.02 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4060941 | — | — | 1 | 6.72 |
| CHEMBL4062129 | — | — | 1 | 6.70 |
| CHEMBL4080636 | — | — | 1 | 6.55 |
| CHEMBL4096415 | — | — | 1 | 6.43 |
| CHEMBL4089123 | — | — | 1 | 6.35 |
| CHEMBL4061348 | — | — | 1 | 6.24 |
| CHEMBL4066911 | — | — | 1 | 6.22 |
| CHEMBL1701908 | — | — | 1 | 6.14 |
| CHEMBL4071635 | — | — | 1 | 6.07 |
| CHEMBL247879 | — | — | 1 | 6.05 |
| CHEMBL4079708 | — | — | 1 | 6.05 |
| CHEMBL1492375 | — | — | 1 | 6.04 |
| CHEMBL3717926 | — | — | 1 | 5.96 |
| CHEMBL1317843 | — | — | 1 | 5.96 |
| CHEMBL4068934 | — | — | 1 | 5.92 |
| CHEMBL4077916 | — | — | 1 | 5.85 |
| CHEMBL393713 | — | — | 1 | 5.85 |
| CHEMBL4099630 | — | — | 1 | 5.85 |
| CHEMBL4077882 | — | — | 1 | 5.82 |
| CHEMBL4097740 | — | — | 1 | 5.82 |
| CHEMBL4097159 | — | — | 1 | 5.80 |
| CHEMBL4104868 | — | — | 1 | 5.80 |
| CHEMBL4080322 | — | — | 1 | 5.77 |
| CHEMBL4098653 | — | — | 1 | 5.75 |
| CHEMBL4095961 | — | — | 1 | 5.66 |
| CHEMBL4069960 | — | — | 1 | 5.08 |
| CHEMBL4081583 | — | — | 1 | - |
| CHEMBL4060259 | — | — | 1 | - |
| CHEMBL4087587 | — | — | 1 | - |
| CHEMBL595840 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4060941 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4062129 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4080636 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4096415 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4089123 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4061348 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4066911 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1701908 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4071635 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL247879 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4079708 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL1492375 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3717926 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1317843 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4068934 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4077916 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL393713 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4099630 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4077882 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4097740 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4097159 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4104868 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4080322 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4098653 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4095961 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4069960 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4081583 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4060259 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4087587 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL595840 | — | IC50 | > | 100000.0 | nM | - |