Assay Detail
Binding
CHEMBL4044350
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U-69,593 from human kappa opioid receptor expressed in CHO cell membranes by microbeta scintillation counting analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.17 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2059382 | — | — | 1 | 7.56 |
| CHEMBL3632690 | — | — | 1 | 7.54 |
| CHEMBL252172 | BNTX | — | 1 | 7.48 |
| CHEMBL4105306 | — | — | 1 | 7.46 |
| CHEMBL4081053 | — | — | 1 | 7.31 |
| CHEMBL4071324 | — | — | 1 | 7.15 |
| CHEMBL4070277 | — | — | 1 | 7.11 |
| CHEMBL2059381 | — | — | 1 | 6.97 |
| CHEMBL4092119 | — | — | 1 | 6.90 |
| CHEMBL4061882 | — | — | 1 | 6.75 |
| CHEMBL4089193 | — | — | 1 | 6.68 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | - |
| CHEMBL4090365 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2059382 | — | Ki | = | 27.8 | nM | 7.56 |
| CHEMBL3632690 | — | Ki | = | 28.6 | nM | 7.54 |
| CHEMBL252172 | BNTX | Ki | = | 32.8 | nM | 7.48 |
| CHEMBL4105306 | — | Ki | = | 35.1 | nM | 7.46 |
| CHEMBL4081053 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL4071324 | — | Ki | = | 70.4 | nM | 7.15 |
| CHEMBL4070277 | — | Ki | = | 78.6 | nM | 7.11 |
| CHEMBL2059381 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL4092119 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL4061882 | — | Ki | = | 176.0 | nM | 6.75 |
| CHEMBL4089193 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL137 | METRONIDAZOLE | Ki | - | — | - | |
| CHEMBL4090365 | — | Ki | > | 1000.0 | nM | - |