Assay Detail
Binding
CHEMBL4044353
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Displacement of [3H]spiperone from human D2short receptor expressed in CHO cell membranes by radioligand binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent haloperidol derivatives covalently binding to the dopamine D2 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.88 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.60 |
| CHEMBL4086894 | — | — | 1 | 7.14 |
| CHEMBL4100263 | — | — | 1 | 6.85 |
| CHEMBL4082245 | — | — | 1 | 6.03 |
| CHEMBL4065455 | — | — | 1 | 5.82 |
| CHEMBL4071729 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL4086894 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL4100263 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4082245 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL4065455 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL4071729 | — | Ki | = | 1500.0 | nM | 5.82 |