Assay Detail
Binding
CHEMBL4044354
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human D2short receptor L2.64C mutant expressed in HEK293T cell membranes by radioligand binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potent haloperidol derivatives covalently binding to the dopamine D2 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.28 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100263 | — | — | 1 | 6.50 |
| CHEMBL4086894 | — | — | 1 | 6.48 |
| CHEMBL4065455 | — | — | 1 | 6.26 |
| CHEMBL4082245 | — | — | 1 | 6.07 |
| CHEMBL4071729 | — | — | 1 | 6.07 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100263 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL4086894 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL4065455 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL4082245 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL4071729 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL54 | HALOPERIDOL | Ki | - | — | - |