Assay Detail
Binding
CHEMBL4044566
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at New Zealand rabbit L-type calcium channel assessed as dilation of K+-depolarization induced basilary artery contraction measured after 20 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A novel antihypertension agent, sargachromenol D from marine brown algae, Sargassum siliquastrum, exerts dual action as an L-type Ca2+ channel blocker and endothelin A/B2 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.84 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1428 | NIMODIPINE | 4.0 | 1 | 6.28 |
| CHEMBL465202 | SARGACHROMANO D | — | 1 | 5.79 |
| CHEMBL4079386 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1428 | NIMODIPINE | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL465202 | SARGACHROMANO D | EC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4079386 | — | EC50 | = | 3520.0 | nM | 5.45 |