Assay Detail
Binding
CHEMBL4044676
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Inhibition of EHMT1 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase EHMT1 (CHEMBL6031) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cycloalkane analogues of sinefungin as EHMT1/2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.96 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1231795 | — | — | 1 | 7.72 |
| CHEMBL1214186 | SINEFUNGIN | 2.0 | 1 | 7.00 |
| CHEMBL569864 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1231795 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1214186 | SINEFUNGIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL569864 | — | IC50 | = | 700.0 | nM | 6.16 |