Assay Detail
Binding
CHEMBL4044718
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Competitive inhibition of coffee beans alpha-galactosidase pre-incubated for 1 hr followed by p-nitrophenyl-alpha-D-galactopyranoside substrate addition by fluorescence detection based assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Coffea arabica |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
α-Geminal disubstituted pyrrolidine iminosugars and their C-4-fluoro analogues: Synthesis, glycosidase inhibition and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.45 | 7.80 |
| Ki | 2 | 7.66 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4073111 | — | — | 2 | 8.10 |
| CHEMBL4096086 | — | — | 2 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4073111 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL4073111 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4096086 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL4096086 | — | IC50 | = | 79.0 | nM | 7.10 |