Assay Detail
Binding
CHEMBL4044731
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HSL in rat adipocytes assessed as reduction in lipolysis by measuring glycerol concentration incubated for 30 mins by spectrophotometric analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.69 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4063918 | — | — | 1 | 7.62 |
| CHEMBL4085494 | — | — | 1 | 7.35 |
| CHEMBL4075264 | — | — | 1 | 7.17 |
| CHEMBL4102589 | — | — | 1 | 7.10 |
| CHEMBL4063082 | — | — | 1 | 6.96 |
| CHEMBL4059792 | — | — | 1 | 6.89 |
| CHEMBL4072513 | — | — | 1 | 6.75 |
| CHEMBL4082999 | — | — | 1 | 6.58 |
| CHEMBL4100977 | — | — | 1 | 6.55 |
| CHEMBL4062547 | — | — | 1 | 6.33 |
| CHEMBL4064703 | — | — | 1 | 5.96 |
| CHEMBL4078327 | — | — | 1 | 5.85 |
| CHEMBL4081717 | — | — | 1 | 5.85 |
| CHEMBL4093246 | — | — | 1 | - |
| CHEMBL4101916 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4063918 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4085494 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4075264 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4102589 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4063082 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4059792 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4072513 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4082999 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4100977 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4062547 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4064703 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4078327 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4081717 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4093246 | — | IC50 | - | — | - | |
| CHEMBL4101916 | — | IC50 | - | — | - |