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Assay Detail

CHEMBL4044890

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to wild-type avi-tagged BCL6 BTB domain (unknown origin) by SPR analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

B-cell lymphoma 6 protein (CHEMBL4105786)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.
Yasui T, Yamamoto T, Sakai N, Asano K, Takai T, Yoshitomi Y, Davis M, Takagi T, Sakamoto K, Sogabe S, Kamada Y, Lane W, Snell G, Iwata M, Goto M, Inooka H, Sakamoto JI, Nakada Y, Imaeda Y.
Bioorg Med Chem (2017) 25 : 4876 -4886
PubMed 28760529 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 4.96 5.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4063725 1 5.30
CHEMBL4096591 1 4.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4063725 Kd = 5000.0 nM 5.30
CHEMBL4096591 Kd = 24000.0 nM 4.62