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Assay Detail

CHEMBL4044902

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to recombinant RED-NHS labelled BCL6 BTB domain (1 to 129 residues) (unknown origin) after 10 mins by microscale thermophoresis method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

B-cell lymphoma 6 protein (CHEMBL4105786)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.
Yasui T, Yamamoto T, Sakai N, Asano K, Takai T, Yoshitomi Y, Davis M, Takagi T, Sakamoto K, Sogabe S, Kamada Y, Lane W, Snell G, Iwata M, Goto M, Inooka H, Sakamoto JI, Nakada Y, Imaeda Y.
Bioorg Med Chem (2017) 25 : 4876 -4886
PubMed 28760529 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 5.16 5.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4061302 1 5.16
CHEMBL4066375 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4061302 Kd = 7000.0 nM 5.16
CHEMBL4066375 Kd = 129000.0 nM -