Assay Detail
Binding
CHEMBL4044916
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PIM1 in presence of ATP by ELISA based spectrophotometric analysis
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure based drug design of Pim-1 kinase followed by pharmacophore guided synthesis of quinolone-based inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.07 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1952142 | — | — | 1 | 9.00 |
| CHEMBL1782530 | — | — | 1 | 9.00 |
| CHEMBL4087294 | — | — | 1 | 8.70 |
| CHEMBL4105153 | — | — | 1 | 8.70 |
| CHEMBL4090634 | — | — | 1 | 8.70 |
| CHEMBL4062679 | — | — | 1 | 8.70 |
| CHEMBL4087212 | — | — | 1 | 8.70 |
| CHEMBL4102644 | — | — | 1 | 8.70 |
| CHEMBL1915449 | — | — | 1 | 8.70 |
| CHEMBL2035636 | — | — | 1 | 8.52 |
| CHEMBL2035629 | — | — | 1 | 8.52 |
| CHEMBL2035628 | — | — | 1 | 8.40 |
| CHEMBL1952126 | — | — | 1 | 8.40 |
| CHEMBL4073348 | — | — | 1 | 8.40 |
| CHEMBL1915438 | — | — | 1 | 8.30 |
| CHEMBL1952134 | — | — | 1 | 8.30 |
| CHEMBL1915635 | — | — | 1 | 8.22 |
| CHEMBL1952144 | — | — | 1 | 8.22 |
| CHEMBL1915642 | — | — | 1 | 8.15 |
| CHEMBL4070120 | — | — | 1 | 8.15 |
| CHEMBL1915443 | — | — | 1 | 8.15 |
| CHEMBL1952329 | SGI-1776 | 1.0 | 1 | 8.15 |
| CHEMBL1915633 | — | — | 1 | 8.10 |
| CHEMBL1952136 | — | — | 1 | 8.05 |
| CHEMBL2035632 | — | — | 1 | 8.05 |
| CHEMBL4077340 | — | — | 1 | 6.53 |
| CHEMBL4101797 | — | — | 1 | 5.67 |
| CHEMBL4078430 | — | — | 1 | 5.48 |
| CHEMBL4083792 | — | — | 1 | 5.47 |
| CHEMBL4086292 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1952142 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1782530 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4087294 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4105153 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4090634 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4062679 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4087212 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4102644 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1915449 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2035636 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2035629 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2035628 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1952126 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4073348 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1915438 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1952134 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1915635 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1952144 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1915642 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4070120 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1915443 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1952329 | SGI-1776 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1915633 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1952136 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2035632 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4077340 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL4101797 | — | IC50 | = | 2124.0 | nM | 5.67 |
| CHEMBL4078430 | — | IC50 | = | 3335.0 | nM | 5.48 |
| CHEMBL4083792 | — | IC50 | = | 3387.0 | nM | 5.47 |
| CHEMBL4086292 | — | IC50 | = | 54871000.0 | nM | - |
| CHEMBL4102686 | — | IC50 | = | 56511000.0 | nM | - |