Assay Detail
Functional
CHEMBL4045008
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Antiproliferative activity against human MV4-11 cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.67 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4064933 | — | — | 1 | 6.25 |
| CHEMBL4096161 | — | — | 1 | 6.04 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.01 |
| CHEMBL4103392 | — | — | 1 | 5.86 |
| CHEMBL4079901 | — | — | 1 | 5.78 |
| CHEMBL4091222 | — | — | 1 | 5.71 |
| CHEMBL4094944 | — | — | 1 | 5.65 |
| CHEMBL4091545 | — | — | 1 | 5.37 |
| CHEMBL2393130 | APABETALONE | 3.0 | 1 | 5.35 |
| CHEMBL4096923 | — | — | 1 | 5.30 |
| CHEMBL4064918 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4064933 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4096161 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4103392 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4079901 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4091222 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL4094944 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4091545 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL2393130 | APABETALONE | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL4096923 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4064918 | — | IC50 | = | 9880.0 | nM | 5.00 |