Assay Detail
Functional
CHEMBL4045014
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Antiproliferative activity against human OCI-AML3 cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OCI-AML-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.63 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4064933 | — | — | 1 | 6.37 |
| CHEMBL4096161 | — | — | 1 | 6.17 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.07 |
| CHEMBL4079901 | — | — | 1 | 5.96 |
| CHEMBL4091222 | — | — | 1 | 5.75 |
| CHEMBL4094944 | — | — | 1 | 5.74 |
| CHEMBL4103392 | — | — | 1 | 5.52 |
| CHEMBL4096923 | — | — | 1 | 5.26 |
| CHEMBL2393130 | APABETALONE | 3.0 | 1 | 5.14 |
| CHEMBL4064918 | — | — | 1 | 5.03 |
| CHEMBL4091545 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4064933 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4096161 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4079901 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4091222 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4094944 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL4103392 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL4096923 | — | IC50 | = | 5530.0 | nM | 5.26 |
| CHEMBL2393130 | APABETALONE | IC50 | = | 7170.0 | nM | 5.14 |
| CHEMBL4064918 | — | IC50 | = | 9310.0 | nM | 5.03 |
| CHEMBL4091545 | — | IC50 | = | 11130.0 | nM | 4.95 |