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Assay Detail

CHEMBL4045040

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF7/Topo cells after 72 hrs by MTT assay
30
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7/Topo
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Fluoro and pentafluorothio analogs of the antitumoral curcuminoid EF24 with superior antiangiogenic and vascular-disruptive effects.
Schmitt F, Gold M, Begemann G, Andronache I, Biersack B, Schobert R.
Bioorg Med Chem (2017) 25 : 4894 -4903
PubMed 28774574 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.82 6.40
Activity 15 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4099523 2 6.40
CHEMBL4091786 2 6.12
CHEMBL4089381 2 6.00
CHEMBL4061229 2 5.96
CHEMBL4075661 2 5.89
CHEMBL4103646 2 5.80
CHEMBL4070918 2 5.80
CHEMBL4069893 2 5.75
CHEMBL4084013 2 5.75
CHEMBL4097090 2 5.70
CHEMBL4085714 2 5.68
CHEMBL4081505 2 5.68
CHEMBL379849 2 5.66
CHEMBL2386412 2 5.64
CHEMBL4062301 2 5.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4099523 IC50 = 400.0 nM 6.40
CHEMBL4091786 IC50 = 760.0 nM 6.12
CHEMBL4089381 IC50 = 1000.0 nM 6.00
CHEMBL4061229 IC50 = 1100.0 nM 5.96
CHEMBL4075661 IC50 = 1300.0 nM 5.89
CHEMBL4103646 IC50 = 1600.0 nM 5.80
CHEMBL4070918 IC50 = 1600.0 nM 5.80
CHEMBL4069893 IC50 = 1800.0 nM 5.75
CHEMBL4084013 IC50 = 1800.0 nM 5.75
CHEMBL4097090 IC50 = 2000.0 nM 5.70
CHEMBL4081505 IC50 = 2100.0 nM 5.68
CHEMBL4085714 IC50 = 2100.0 nM 5.68
CHEMBL379849 IC50 = 2200.0 nM 5.66
CHEMBL2386412 IC50 = 2300.0 nM 5.64
CHEMBL4062301 IC50 = 3400.0 nM 5.47
CHEMBL379849 Activity - -
CHEMBL2386412 Activity - -
CHEMBL4075661 Activity - -
CHEMBL4103646 Activity - -
CHEMBL4085714 Activity - -
CHEMBL4097090 Activity - -
CHEMBL4069893 Activity - -
CHEMBL4089381 Activity - -
CHEMBL4061229 Activity - -
CHEMBL4081505 Activity - -
CHEMBL4099523 Activity - -
CHEMBL4070918 Activity - -
CHEMBL4091786 Activity - -
CHEMBL4062301 Activity - -
CHEMBL4084013 Activity - -