Assay Detail
Functional
CHEMBL4045104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at dopamine D2 receptor (unknown origin) after 60 mins by Ultra lance cAMP assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.71 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061068 | — | — | 1 | 8.62 |
| CHEMBL4083333 | — | — | 1 | 8.58 |
| CHEMBL4090872 | — | — | 1 | 8.54 |
| CHEMBL4102670 | — | — | 1 | 8.48 |
| CHEMBL4094825 | — | — | 1 | 8.48 |
| CHEMBL4104261 | — | — | 1 | 8.48 |
| CHEMBL4087132 | — | — | 1 | 8.46 |
| CHEMBL4096467 | — | — | 1 | 8.30 |
| CHEMBL4060678 | — | — | 1 | 8.29 |
| CHEMBL4062992 | — | — | 1 | 8.28 |
| CHEMBL4079251 | — | — | 1 | 8.26 |
| CHEMBL4062936 | — | — | 1 | 8.21 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.15 |
| CHEMBL4084663 | — | — | 1 | 8.12 |
| CHEMBL4074373 | — | — | 1 | 8.11 |
| CHEMBL4101115 | — | — | 1 | 8.08 |
| CHEMBL1621 | PALIPERIDONE | 4.0 | 1 | 8.08 |
| CHEMBL4077702 | — | — | 1 | 8.04 |
| CHEMBL4074326 | — | — | 1 | 8.03 |
| CHEMBL4098594 | — | — | 1 | 8.02 |
| CHEMBL4078409 | — | — | 1 | 7.98 |
| CHEMBL4087246 | — | — | 1 | 7.93 |
| CHEMBL4097395 | — | — | 1 | 7.70 |
| CHEMBL4102561 | — | — | 1 | 7.57 |
| CHEMBL4100152 | — | — | 1 | 7.57 |
| CHEMBL4065710 | — | — | 1 | 7.50 |
| CHEMBL4077006 | — | — | 1 | 7.44 |
| CHEMBL4079365 | — | — | 1 | 7.42 |
| CHEMBL4103509 | — | — | 1 | 7.39 |
| CHEMBL4094926 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061068 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4083333 | — | IC50 | = | 2.61 | nM | 8.58 |
| CHEMBL4090872 | — | IC50 | = | 2.87 | nM | 8.54 |
| CHEMBL4102670 | — | IC50 | = | 3.31 | nM | 8.48 |
| CHEMBL4094825 | — | IC50 | = | 3.29 | nM | 8.48 |
| CHEMBL4104261 | — | IC50 | = | 3.32 | nM | 8.48 |
| CHEMBL4087132 | — | IC50 | = | 3.51 | nM | 8.46 |
| CHEMBL4096467 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4060678 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4062992 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4079251 | — | IC50 | = | 5.49 | nM | 8.26 |
| CHEMBL4062936 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL85 | RISPERIDONE | IC50 | = | 7.09 | nM | 8.15 |
| CHEMBL4084663 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4074373 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4101115 | — | IC50 | = | 8.29 | nM | 8.08 |
| CHEMBL1621 | PALIPERIDONE | IC50 | = | 8.28 | nM | 8.08 |
| CHEMBL4077702 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4074326 | — | IC50 | = | 9.44 | nM | 8.03 |
| CHEMBL4098594 | — | IC50 | = | 9.65 | nM | 8.02 |
| CHEMBL4078409 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL4087246 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL4097395 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4102561 | — | IC50 | = | 26.7 | nM | 7.57 |
| CHEMBL4100152 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4065710 | — | IC50 | = | 31.5 | nM | 7.50 |
| CHEMBL4077006 | — | IC50 | = | 36.6 | nM | 7.44 |
| CHEMBL4079365 | — | IC50 | = | 37.6 | nM | 7.42 |
| CHEMBL4103509 | — | IC50 | = | 40.5 | nM | 7.39 |
| CHEMBL4094926 | — | IC50 | = | 75.4 | nM | 7.12 |
| CHEMBL4082084 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4067506 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL4082150 | — | IC50 | = | 875.0 | nM | 6.06 |
| CHEMBL4091554 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4063748 | — | IC50 | = | 5530.0 | nM | 5.26 |
| CHEMBL4064609 | — | IC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL4105102 | — | IC50 | > | 10000.0 | nM | - |