Assay Detail
Functional
CHEMBL4045106
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.57 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4083333 | — | — | 1 | 8.92 |
| CHEMBL4098594 | — | — | 1 | 8.54 |
| CHEMBL4102670 | — | — | 1 | 8.54 |
| CHEMBL4061068 | — | — | 1 | 8.47 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.33 |
| CHEMBL4060678 | — | — | 1 | 8.29 |
| CHEMBL4078409 | — | — | 1 | 8.29 |
| CHEMBL1621 | PALIPERIDONE | 4.0 | 1 | 8.28 |
| CHEMBL4084663 | — | — | 1 | 8.19 |
| CHEMBL4096467 | — | — | 1 | 8.15 |
| CHEMBL4094926 | — | — | 1 | 8.12 |
| CHEMBL4094825 | — | — | 1 | 8.04 |
| CHEMBL4065710 | — | — | 1 | 8.02 |
| CHEMBL4082084 | — | — | 1 | 8.02 |
| CHEMBL4077702 | — | — | 1 | 8.00 |
| CHEMBL4104261 | — | — | 1 | 7.99 |
| CHEMBL4087132 | — | — | 1 | 7.94 |
| CHEMBL4079251 | — | — | 1 | 7.91 |
| CHEMBL4062992 | — | — | 1 | 7.77 |
| CHEMBL4090872 | — | — | 1 | 7.67 |
| CHEMBL4062936 | — | — | 1 | 7.60 |
| CHEMBL4097395 | — | — | 1 | 7.58 |
| CHEMBL4087246 | — | — | 1 | 7.58 |
| CHEMBL4079365 | — | — | 1 | 7.46 |
| CHEMBL4074326 | — | — | 1 | 7.42 |
| CHEMBL4103509 | — | — | 1 | 7.36 |
| CHEMBL4101115 | — | — | 1 | 7.22 |
| CHEMBL4091554 | — | — | 1 | 7.18 |
| CHEMBL4102561 | — | — | 1 | 7.15 |
| CHEMBL4074373 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4083333 | — | IC50 | = | 1.19 | nM | 8.92 |
| CHEMBL4098594 | — | IC50 | = | 2.87 | nM | 8.54 |
| CHEMBL4102670 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4061068 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL85 | RISPERIDONE | IC50 | = | 4.67 | nM | 8.33 |
| CHEMBL4060678 | — | IC50 | = | 5.18 | nM | 8.29 |
| CHEMBL4078409 | — | IC50 | = | 5.12 | nM | 8.29 |
| CHEMBL1621 | PALIPERIDONE | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4084663 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4096467 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4094926 | — | IC50 | = | 7.66 | nM | 8.12 |
| CHEMBL4094825 | — | IC50 | = | 9.14 | nM | 8.04 |
| CHEMBL4065710 | — | IC50 | = | 9.49 | nM | 8.02 |
| CHEMBL4082084 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL4077702 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4104261 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL4087132 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL4079251 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL4062992 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4090872 | — | IC50 | = | 21.46 | nM | 7.67 |
| CHEMBL4062936 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4097395 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL4087246 | — | IC50 | = | 26.4 | nM | 7.58 |
| CHEMBL4079365 | — | IC50 | = | 34.4 | nM | 7.46 |
| CHEMBL4074326 | — | IC50 | = | 37.6 | nM | 7.42 |
| CHEMBL4103509 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4101115 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4091554 | — | IC50 | = | 65.4 | nM | 7.18 |
| CHEMBL4102561 | — | IC50 | = | 71.3 | nM | 7.15 |
| CHEMBL4074373 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4100152 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL4077006 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL4067506 | — | IC50 | = | 651.0 | nM | 6.19 |
| CHEMBL4063748 | — | IC50 | = | 814.0 | nM | 6.09 |
| CHEMBL4064609 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4082150 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL4105102 | — | IC50 | = | 2300.0 | nM | 5.64 |