Assay Detail
ADMET
CHEMBL4045107
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Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.22 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4094825 | — | — | 1 | 8.05 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.96 |
| CHEMBL4104261 | — | — | 1 | 6.91 |
| CHEMBL4102670 | — | — | 1 | 6.82 |
| CHEMBL4083333 | — | — | 1 | 6.81 |
| CHEMBL4087132 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4094825 | — | IC50 | = | 8.99 | nM | 8.05 |
| CHEMBL85 | RISPERIDONE | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL4104261 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL4102670 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL4083333 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL4087132 | — | IC50 | = | 174.0 | nM | 6.76 |