Assay Detail
Binding
CHEMBL4045110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.46 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 5.88 |
| CHEMBL4083333 | — | — | 1 | 5.57 |
| CHEMBL4102670 | — | — | 1 | 5.39 |
| CHEMBL4087132 | — | — | 1 | 5.24 |
| CHEMBL4104261 | — | — | 1 | 5.21 |
| CHEMBL4094825 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL4083333 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL4102670 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL4087132 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4104261 | — | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL4094825 | — | IC50 | - | — | - |