Assay Detail
Functional
CHEMBL4045248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimigratory activity against MDCK2 cells assessed as inhibition of HGF-induced cell scattering pretreated for 18 hrs followed by HGF addition measured after 20 to 24 hrs by crystal violet staining-based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Cell Type | MDCK-II |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyridine-pyrimidine amides that prevent HGF-induced epithelial scattering by two distinct mechanisms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 5.52 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4075481 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4075481 | — | EC50 | = | 3000.0 | nM | 5.52 |