Assay Detail
Functional
CHEMBL4045491
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Antiparasitic activity against Leishmania donovani MHOM-ET-67/L82 axenic amastigotes after 72 hrs by Alamar blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.20 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4060175 | — | — | 1 | 6.64 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 6.60 |
| CHEMBL4104679 | — | — | 1 | 6.44 |
| CHEMBL4063225 | — | — | 1 | 6.21 |
| CHEMBL4070437 | — | — | 1 | 6.19 |
| CHEMBL4068026 | — | — | 1 | 6.14 |
| CHEMBL4070401 | — | — | 1 | 6.12 |
| CHEMBL4094002 | — | — | 1 | 5.82 |
| CHEMBL4075894 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4060175 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4104679 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4063225 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4070437 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4068026 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4070401 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4094002 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4075894 | — | IC50 | = | 2160.0 | nM | 5.67 |