Assay Detail
Functional
CHEMBL4045493
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against intraerythrocytic form of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 infected in human RBC preincubated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 8 | - | - |
| IC50 | 3 | 6.08 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.60 |
| CHEMBL4075894 | — | — | 1 | 5.82 |
| CHEMBL4094002 | — | — | 1 | 5.82 |
| CHEMBL1885822 | — | — | 1 | - |
| CHEMBL4072453 | — | — | 1 | - |
| CHEMBL517496 | — | — | 1 | - |
| CHEMBL4064884 | — | — | 1 | - |
| CHEMBL4102778 | — | — | 1 | - |
| CHEMBL4095965 | — | — | 1 | - |
| CHEMBL4076450 | — | — | 1 | - |
| CHEMBL82224 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4075894 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4094002 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1885822 | — | Activity | - | — | - | |
| CHEMBL4072453 | — | Activity | - | — | - | |
| CHEMBL517496 | — | Activity | - | — | - | |
| CHEMBL4064884 | — | Activity | - | — | - | |
| CHEMBL4102778 | — | Activity | - | — | - | |
| CHEMBL4095965 | — | Activity | - | — | - | |
| CHEMBL4076450 | — | Activity | - | — | - | |
| CHEMBL82224 | — | Activity | - | — | - |