Assay Detail
Binding
CHEMBL4045528
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Inhibition of human CA12 pre-incubated for 10 mins by stopped-flow CO2 hydrase assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.37 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL4074017 | — | — | 1 | 7.70 |
| CHEMBL4081833 | — | — | 1 | 7.58 |
| CHEMBL4084340 | — | — | 1 | 7.55 |
| CHEMBL4092096 | — | — | 1 | 7.40 |
| CHEMBL2377778 | — | — | 1 | 7.37 |
| CHEMBL4099375 | — | — | 1 | 7.37 |
| CHEMBL4061148 | — | — | 1 | 7.33 |
| CHEMBL4073974 | — | — | 1 | 7.33 |
| CHEMBL4098904 | — | — | 1 | 7.32 |
| CHEMBL2377779 | — | — | 1 | 7.29 |
| CHEMBL4099996 | — | — | 1 | 7.13 |
| CHEMBL4072442 | — | — | 1 | 7.09 |
| CHEMBL4069126 | — | — | 1 | 7.07 |
| CHEMBL4071301 | — | — | 1 | 7.07 |
| CHEMBL4099836 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL4074017 | — | Ki | = | 19.9 | nM | 7.70 |
| CHEMBL4081833 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4084340 | — | Ki | = | 28.3 | nM | 7.55 |
| CHEMBL4092096 | — | Ki | = | 39.9 | nM | 7.40 |
| CHEMBL2377778 | — | Ki | = | 42.8 | nM | 7.37 |
| CHEMBL4099375 | — | Ki | = | 42.8 | nM | 7.37 |
| CHEMBL4061148 | — | Ki | = | 46.9 | nM | 7.33 |
| CHEMBL4073974 | — | Ki | = | 47.2 | nM | 7.33 |
| CHEMBL4098904 | — | Ki | = | 47.7 | nM | 7.32 |
| CHEMBL2377779 | — | Ki | = | 51.7 | nM | 7.29 |
| CHEMBL4099996 | — | Ki | = | 74.1 | nM | 7.13 |
| CHEMBL4072442 | — | Ki | = | 80.5 | nM | 7.09 |
| CHEMBL4069126 | — | Ki | = | 84.6 | nM | 7.07 |
| CHEMBL4071301 | — | Ki | = | 84.4 | nM | 7.07 |
| CHEMBL4099836 | — | Ki | = | 90.3 | nM | 7.04 |