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Assay Detail

CHEMBL4046198

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human Huh7.5.1 cells assessed as reduction in cell viability by cell titer 96 aqueous one solution cell proliferation assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Huh7.5.1
Confidence 1 — Organism
Curated By Autocuration

Target

Huh7.5.1 (CHEMBL4483247)
Type CELL-LINE
Organism Homo sapiens

Publication

Chemoselective fluorination and chemoinformatic analysis of griseofulvin: Natural vs fluorinated fungal metabolites.
Paguigan ND, Al-Huniti MH, Raja HA, Czarnecki A, Burdette JE, González-Medina M, Medina-Franco JL, Polyak SJ, Pearce CJ, Croatt MP, Oberlies NH.
Bioorg Med Chem (2017) 25 : 5238 -5246
PubMed 28802670 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.00 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4081961 1 5.00
CHEMBL562 GRISEOFULVIN 4.0 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4081961 IC50 = 10000.0 nM 5.00
CHEMBL562 GRISEOFULVIN IC50 = 10000.0 nM 5.00