Assay Detail
Functional
CHEMBL4046207
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Constructing novel dihydrofuran and dihydroisoxazole analogues of isocombretastatin-4 as tubulin polymerization inhibitors through [3+2] reactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.70 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL498271 | — | — | 1 | 7.07 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.28 |
| CHEMBL4090990 | — | — | 1 | 5.63 |
| CHEMBL4094372 | — | — | 1 | 5.49 |
| CHEMBL4073778 | — | — | 1 | 5.48 |
| CHEMBL4098725 | — | — | 1 | 5.35 |
| CHEMBL4073397 | — | — | 1 | 5.14 |
| CHEMBL4099227 | — | — | 1 | 5.12 |
| CHEMBL4076789 | — | — | 1 | - |
| CHEMBL4065320 | — | — | 1 | - |
| CHEMBL4069032 | — | — | 1 | - |
| CHEMBL4061832 | — | — | 1 | - |
| CHEMBL4063761 | — | — | 1 | - |
| CHEMBL4101777 | — | — | 1 | - |
| CHEMBL4083781 | — | — | 1 | - |
| CHEMBL4094044 | — | — | 1 | - |
| CHEMBL4085243 | — | — | 1 | - |
| CHEMBL4103172 | — | — | 1 | - |
| CHEMBL4092985 | — | — | 1 | - |
| CHEMBL4093981 | — | — | 1 | - |
| CHEMBL4073312 | — | — | 1 | - |
| CHEMBL4090569 | — | — | 1 | - |
| CHEMBL4069556 | — | — | 1 | - |
| CHEMBL4098300 | — | — | 1 | - |
| CHEMBL4080260 | — | — | 1 | - |
| CHEMBL4072272 | — | — | 1 | - |
| CHEMBL4082755 | — | — | 1 | - |
| CHEMBL4060890 | — | — | 1 | - |
| CHEMBL4080677 | — | — | 1 | - |
| CHEMBL4088550 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL498271 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4090990 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL4094372 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL4073778 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL4098725 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL4073397 | — | IC50 | = | 7210.0 | nM | 5.14 |
| CHEMBL4099227 | — | IC50 | = | 7570.0 | nM | 5.12 |
| CHEMBL4083781 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4091564 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4094044 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4085243 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4103172 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4092985 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4065320 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4100704 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4060324 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4099303 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4072351 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4060963 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4082843 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4083199 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4075420 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4070009 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4101777 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4063761 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4061832 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4069032 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4076789 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4093981 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4073312 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4090569 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4069556 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4098300 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4080260 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4072272 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4082755 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4060890 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4080677 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4088550 | — | IC50 | > | 10000.0 | nM | - |