Assay Detail
Binding
CHEMBL4046296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged Trypanosoma brucei AdoMetDC expressed in Escherichia coli pre-incubated for 1 to 22 mins before AdoMet substrate addition
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.54 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL512274 | — | — | 1 | 7.68 |
| CHEMBL381751 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL512274 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL381751 | — | IC50 | = | 41.0 | nM | 7.39 |