Assay Detail
ADMET
CHEMBL4046590
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Inhibition of JAK2 (unknown origin) by biochemical assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.19 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4070262 | — | — | 1 | 8.27 |
| CHEMBL4093872 | — | — | 1 | 8.19 |
| CHEMBL4093172 | — | — | 1 | 8.18 |
| CHEMBL4080904 | — | — | 1 | 8.00 |
| CHEMBL4097446 | — | — | 1 | 7.85 |
| CHEMBL4084436 | — | — | 1 | 7.85 |
| CHEMBL4082575 | — | — | 1 | 7.80 |
| CHEMBL4075453 | — | — | 1 | 7.80 |
| CHEMBL4062758 | — | — | 1 | 7.68 |
| CHEMBL4076947 | — | — | 1 | 7.66 |
| CHEMBL4092116 | — | — | 1 | 7.64 |
| CHEMBL3675685 | — | — | 1 | 7.58 |
| CHEMBL4071399 | — | — | 1 | 7.58 |
| CHEMBL2387224 | — | — | 1 | 7.55 |
| CHEMBL4069942 | — | — | 1 | 7.47 |
| CHEMBL4062680 | — | — | 1 | 7.44 |
| CHEMBL4065419 | — | — | 1 | 7.37 |
| CHEMBL2387223 | — | — | 1 | 7.21 |
| CHEMBL4092191 | — | — | 1 | 7.03 |
| CHEMBL4074130 | — | — | 1 | 7.02 |
| CHEMBL4099854 | — | — | 1 | 6.96 |
| CHEMBL4075131 | — | — | 1 | 6.89 |
| CHEMBL4064189 | — | — | 1 | 6.82 |
| CHEMBL4101734 | — | — | 1 | 6.82 |
| CHEMBL4100889 | — | — | 1 | 6.72 |
| CHEMBL4103341 | — | — | 1 | 6.43 |
| CHEMBL4105148 | — | — | 1 | 6.36 |
| CHEMBL4093092 | — | — | 1 | 6.31 |
| CHEMBL4085414 | — | — | 1 | 6.23 |
| CHEMBL4068427 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4070262 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL4093872 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL4093172 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL4080904 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4097446 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4084436 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4082575 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4075453 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4062758 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL4076947 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL4092116 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL3675685 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4071399 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL2387224 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL4069942 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL4062680 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL4065419 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL2387223 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL4092191 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL4074130 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL4099854 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4075131 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL4064189 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL4101734 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL4100889 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL4103341 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL4105148 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL4093092 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL4085414 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL4068427 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL4089568 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL4086518 | — | Ki | = | 3200.0 | nM | 5.50 |