Assay Detail
ADMET
CHEMBL4046594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK2 (unknown origin) assessed as reduction in EPO-mediated STAT5 phosphorylation by cell based readout assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 5.79 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4093872 | — | — | 1 | 6.34 |
| CHEMBL4062680 | — | — | 1 | 6.21 |
| CHEMBL4071399 | — | — | 1 | 6.19 |
| CHEMBL4097446 | — | — | 1 | 6.09 |
| CHEMBL4075453 | — | — | 1 | 6.00 |
| CHEMBL4070262 | — | — | 1 | 5.96 |
| CHEMBL4080904 | — | — | 1 | 5.96 |
| CHEMBL4084436 | — | — | 1 | 5.89 |
| CHEMBL4076947 | — | — | 1 | 5.85 |
| CHEMBL4092116 | — | — | 1 | 5.80 |
| CHEMBL4062758 | — | — | 1 | 5.72 |
| CHEMBL4069942 | — | — | 1 | 5.68 |
| CHEMBL2387223 | — | — | 1 | 5.65 |
| CHEMBL4099854 | — | — | 1 | 5.19 |
| CHEMBL4092191 | — | — | 1 | 5.11 |
| CHEMBL4105148 | — | — | 1 | 5.00 |
| CHEMBL4065419 | — | — | 1 | - |
| CHEMBL4093092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4093872 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4062680 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4071399 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4097446 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4075453 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4070262 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4080904 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4084436 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4076947 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4092116 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4062758 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4069942 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2387223 | — | EC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL4099854 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4092191 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4105148 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4065419 | — | EC50 | - | — | - | |
| CHEMBL4093092 | — | EC50 | - | — | - |