Assay Detail
Functional
CHEMBL4046663
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV genotype 1b Con1 expressing NS3 protease infected in human Huh-7 cells assessed as reduction in viral RNA replication after 72 hrs by luciferase reporter gene assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 42 | 5.71 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061885 | — | — | 1 | 7.15 |
| CHEMBL4061368 | — | — | 1 | 7.14 |
| CHEMBL4084420 | — | — | 1 | 6.80 |
| CHEMBL4082078 | — | — | 1 | 6.73 |
| CHEMBL3793161 | — | — | 1 | 6.69 |
| CHEMBL4098752 | — | — | 1 | 6.61 |
| CHEMBL4100083 | — | — | 1 | 6.59 |
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | 6.55 |
| CHEMBL4070509 | — | — | 1 | 6.54 |
| CHEMBL4072765 | — | — | 1 | 6.46 |
| CHEMBL4066255 | — | — | 1 | 6.38 |
| CHEMBL4070281 | — | — | 1 | 6.29 |
| CHEMBL4084595 | — | — | 1 | 6.28 |
| CHEMBL4072334 | — | — | 1 | 6.09 |
| CHEMBL4071553 | — | — | 1 | 6.07 |
| CHEMBL4091302 | — | — | 1 | 6.02 |
| CHEMBL4070366 | — | — | 1 | 5.96 |
| CHEMBL4099034 | — | — | 1 | 5.94 |
| CHEMBL4088893 | — | — | 1 | 5.90 |
| CHEMBL1259058 | — | — | 1 | 5.68 |
| CHEMBL4093100 | — | — | 1 | 5.66 |
| CHEMBL4089948 | — | — | 1 | 5.60 |
| CHEMBL4082826 | — | — | 1 | 5.59 |
| CHEMBL4096581 | — | — | 1 | 5.44 |
| CHEMBL4060667 | — | — | 1 | 5.40 |
| CHEMBL4070042 | — | — | 1 | 5.40 |
| CHEMBL4100808 | — | — | 1 | 5.37 |
| CHEMBL4075092 | — | — | 1 | 5.09 |
| CHEMBL4092334 | — | — | 1 | 5.02 |
| CHEMBL4063741 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061885 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4061368 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4084420 | — | EC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4082078 | — | EC50 | = | 185.0 | nM | 6.73 |
| CHEMBL3793161 | — | EC50 | = | 203.0 | nM | 6.69 |
| CHEMBL4098752 | — | EC50 | = | 248.0 | nM | 6.61 |
| CHEMBL4100083 | — | EC50 | = | 257.0 | nM | 6.59 |
| CHEMBL1259059 | SOFOSBUVIR | EC50 | = | 284.0 | nM | 6.55 |
| CHEMBL4070509 | — | EC50 | = | 291.0 | nM | 6.54 |
| CHEMBL4072765 | — | EC50 | = | 351.0 | nM | 6.46 |
| CHEMBL4066255 | — | EC50 | = | 417.0 | nM | 6.38 |
| CHEMBL4070281 | — | EC50 | = | 508.0 | nM | 6.29 |
| CHEMBL4084595 | — | EC50 | = | 528.0 | nM | 6.28 |
| CHEMBL4072334 | — | EC50 | = | 819.0 | nM | 6.09 |
| CHEMBL4071553 | — | EC50 | = | 845.0 | nM | 6.07 |
| CHEMBL4091302 | — | EC50 | = | 953.0 | nM | 6.02 |
| CHEMBL4070366 | — | EC50 | = | 1108.0 | nM | 5.96 |
| CHEMBL4099034 | — | EC50 | = | 1159.0 | nM | 5.94 |
| CHEMBL4088893 | — | EC50 | = | 1269.0 | nM | 5.90 |
| CHEMBL1259058 | — | EC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4093100 | — | EC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL4089948 | — | EC50 | = | 2486.0 | nM | 5.60 |
| CHEMBL4082826 | — | EC50 | = | 2548.0 | nM | 5.59 |
| CHEMBL4096581 | — | EC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL4060667 | — | EC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL4070042 | — | EC50 | = | 4022.0 | nM | 5.40 |
| CHEMBL4100808 | — | EC50 | = | 4283.0 | nM | 5.37 |
| CHEMBL4075092 | — | EC50 | = | 8136.0 | nM | 5.09 |
| CHEMBL4092334 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4063741 | — | EC50 | = | 12030.0 | nM | 4.92 |
| CHEMBL4103415 | — | EC50 | = | 12596.0 | nM | 4.90 |
| CHEMBL2031681 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4091014 | — | EC50 | = | 31834.0 | nM | 4.50 |
| CHEMBL4085344 | — | EC50 | = | 37400.0 | nM | 4.43 |
| CHEMBL4080706 | — | EC50 | = | 42299.0 | nM | 4.37 |
| CHEMBL510394 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3833371 | UPRIFOSBUVIR | EC50 | = | 56800.0 | nM | 4.25 |
| CHEMBL4059905 | — | EC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4104180 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4101761 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4085484 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4097676 | — | EC50 | > | 100000.0 | nM | - |