Assay Detail
Binding
CHEMBL4046665
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Inhibition of wild-type HCV genotype 1b NS5B RNA dependent RNA polymerase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.00 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486231 | GS-461203 | -1.0 | 1 | 7.10 |
| CHEMBL521487 | — | — | 1 | 7.09 |
| CHEMBL4069349 | 4A-TP | -1.0 | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486231 | GS-461203 | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL521487 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4069349 | 4A-TP | IC50 | = | 154.0 | nM | 6.81 |