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Assay Detail

CHEMBL4046895

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine liver beta-galactosidase using 4-nitrophenyl-beta-D-galactopyranoside substrate measured over 240 mins at 10 mins intervals by UV/Vis spectroscopy
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-galactosidase (CHEMBL3482)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Picomolar inhibition of β-galactosidase (bovine liver) attributed to loop closure.
Pickens JB, Wang F, Striegler S.
Bioorg Med Chem (2017) 25 : 5194 -5202
PubMed 28844803 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 7.02 8.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3359124 1 8.04
CHEMBL3359668 1 8.03
CHEMBL3359681 1 7.94
CHEMBL3359123 1 7.82
CHEMBL3359671 1 7.79
CHEMBL3359669 1 7.72
CHEMBL3815031 1 7.67
CHEMBL3359674 1 7.62
CHEMBL3359122 1 7.58
CHEMBL3359677 1 7.38
CHEMBL3359667 1 7.37
CHEMBL4091969 1 7.37
CHEMBL3359682 1 7.34
CHEMBL3359672 1 7.24
CHEMBL3359670 1 6.93
CHEMBL3359666 1 6.38
CHEMBL3752112 1 6.07
CHEMBL3359673 1 5.99
CHEMBL3359684 1 5.06
CHEMBL3753015 1 5.04
CHEMBL3754250 1 4.97
CHEMBL3359680 1 -
CHEMBL3359678 1 -
CHEMBL3359679 1 -
CHEMBL3359683 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3359124 IC50 = 9.1 nM 8.04
CHEMBL3359668 IC50 = 9.4 nM 8.03
CHEMBL3359681 IC50 = 11.6 nM 7.94
CHEMBL3359123 IC50 = 15.2 nM 7.82
CHEMBL3359671 IC50 = 16.2 nM 7.79
CHEMBL3359669 IC50 = 18.9 nM 7.72
CHEMBL3815031 IC50 = 21.6 nM 7.67
CHEMBL3359674 IC50 = 24.1 nM 7.62
CHEMBL3359122 IC50 = 26.2 nM 7.58
CHEMBL3359677 IC50 = 41.3 nM 7.38
CHEMBL3359667 IC50 = 43.1 nM 7.37
CHEMBL4091969 IC50 = 42.7 nM 7.37
CHEMBL3359682 IC50 = 45.4 nM 7.34
CHEMBL3359672 IC50 = 57.6 nM 7.24
CHEMBL3359670 IC50 = 118.0 nM 6.93
CHEMBL3359666 IC50 = 412.0 nM 6.38
CHEMBL3752112 IC50 = 850.0 nM 6.07
CHEMBL3359673 IC50 = 1030.0 nM 5.99
CHEMBL3359684 IC50 = 8700.0 nM 5.06
CHEMBL3753015 IC50 = 9200.0 nM 5.04
CHEMBL3754250 IC50 = 10800.0 nM 4.97
CHEMBL3359680 IC50 > 1400.0 nM -
CHEMBL3359678 IC50 > 1000.0 nM -
CHEMBL3359679 IC50 > 1000.0 nM -
CHEMBL3359683 IC50 > 50000.0 nM -