Assay Detail
Functional
CHEMBL4046945
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Poliovirus 1 LSc-2ab infected in human Hep2 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs by neutral red uptake assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Poliovirus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-enterovirus activity of new analogues of MDL-860.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.37 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097631 | — | — | 1 | 5.57 |
| CHEMBL4090477 | — | — | 1 | 5.57 |
| CHEMBL4079598 | — | — | 1 | 5.17 |
| CHEMBL343131 | — | — | 1 | 5.17 |
| CHEMBL4094262 | — | — | 1 | - |
| CHEMBL4073636 | — | — | 1 | - |
| CHEMBL4101992 | — | — | 1 | - |
| CHEMBL4084003 | — | — | 1 | - |
| CHEMBL4078652 | — | — | 1 | - |
| CHEMBL4102926 | — | — | 1 | - |
| CHEMBL4086499 | — | — | 1 | - |
| CHEMBL4065053 | — | — | 1 | - |
| CHEMBL4069452 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097631 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4090477 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4079598 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL343131 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4094262 | — | IC50 | = | 234000.0 | nM | - |
| CHEMBL4073636 | — | IC50 | - | — | - | |
| CHEMBL4101992 | — | IC50 | - | — | - | |
| CHEMBL4084003 | — | IC50 | - | — | - | |
| CHEMBL4078652 | — | IC50 | - | — | - | |
| CHEMBL4102926 | — | IC50 | - | — | - | |
| CHEMBL4086499 | — | IC50 | - | — | - | |
| CHEMBL4065053 | — | IC50 | - | — | - | |
| CHEMBL4069452 | — | IC50 | - | — | - |