Assay Detail
Functional
CHEMBL4046947
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Antiviral activity against Coxsackievirus B1 Connecticut 5 infected in human Hep2 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs by neutral red uptake assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Coxsackievirus B1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-enterovirus activity of new analogues of MDL-860.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.71 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4079598 | — | — | 1 | 6.16 |
| CHEMBL4097631 | — | — | 1 | 6.12 |
| CHEMBL4090477 | — | — | 1 | 6.10 |
| CHEMBL343131 | — | — | 1 | 6.10 |
| CHEMBL4069452 | — | — | 1 | 4.96 |
| CHEMBL4102926 | — | — | 1 | 4.79 |
| CHEMBL4065053 | — | — | 1 | - |
| CHEMBL4086499 | — | — | 1 | - |
| CHEMBL4078652 | — | — | 1 | - |
| CHEMBL4084003 | — | — | 1 | - |
| CHEMBL4101992 | — | — | 1 | - |
| CHEMBL4073636 | — | — | 1 | - |
| CHEMBL4094262 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4079598 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4097631 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4090477 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL343131 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4069452 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4102926 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL4065053 | — | IC50 | = | 256100.0 | nM | - |
| CHEMBL4086499 | — | IC50 | - | — | - | |
| CHEMBL4078652 | — | IC50 | = | 190100.0 | nM | - |
| CHEMBL4084003 | — | IC50 | - | — | - | |
| CHEMBL4101992 | — | IC50 | - | — | - | |
| CHEMBL4073636 | — | IC50 | - | — | - | |
| CHEMBL4094262 | — | IC50 | = | 152200.0 | nM | - |