Assay Detail
Binding
CHEMBL4046973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human D2LR expressed in CHO cell membranes
22
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
β-Arrestin biased dopamine D2 receptor partial agonists: Synthesis and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.12 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 9.28 |
| CHEMBL4063145 | — | — | 2 | 9.04 |
| CHEMBL4103639 | — | — | 1 | 9.00 |
| CHEMBL4079375 | — | — | 1 | 8.96 |
| CHEMBL4068561 | — | — | 2 | 8.80 |
| CHEMBL4085752 | — | — | 2 | 8.77 |
| CHEMBL4095881 | — | — | 1 | 8.24 |
| CHEMBL4087217 | — | — | 1 | 6.92 |
| CHEMBL4065797 | — | — | 1 | 6.44 |
| CHEMBL4102646 | — | — | 1 | 6.20 |
| CHEMBL4094407 | — | — | 1 | 6.11 |
| CHEMBL4092462 | — | — | 1 | 5.72 |
| CHEMBL4064759 | — | — | 1 | 5.50 |
| CHEMBL4064191 | — | — | 1 | 5.28 |
| CHEMBL4084712 | — | — | 1 | 5.19 |
| CHEMBL4066916 | — | — | 1 | 5.16 |
| CHEMBL4093493 | — | — | 1 | 5.08 |
| CHEMBL4072785 | — | — | 1 | 4.85 |
| CHEMBL4094900 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL4063145 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL4063145 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL4103639 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4079375 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4068561 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4085752 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL4068561 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL4095881 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL4085752 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL4087217 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL4065797 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL4102646 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL4094407 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL4092462 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL4064759 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL4064191 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL4084712 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL4066916 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL4093493 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL4072785 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL4094900 | — | Ki | > | 15000.0 | nM | - |