Assay Detail
Binding
CHEMBL4046974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human D2SR expressed in CHO cell membranes
22
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
β-Arrestin biased dopamine D2 receptor partial agonists: Synthesis and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.38 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 9.42 |
| CHEMBL4068561 | — | — | 2 | 9.27 |
| CHEMBL4103639 | — | — | 1 | 9.24 |
| CHEMBL4063145 | — | — | 2 | 9.17 |
| CHEMBL4079375 | — | — | 1 | 9.14 |
| CHEMBL4085752 | — | — | 2 | 8.96 |
| CHEMBL4095881 | — | — | 1 | 8.54 |
| CHEMBL4087217 | — | — | 1 | 7.46 |
| CHEMBL4065797 | — | — | 1 | 7.25 |
| CHEMBL4102646 | — | — | 1 | 6.70 |
| CHEMBL4094407 | — | — | 1 | 6.60 |
| CHEMBL4092462 | — | — | 1 | 6.32 |
| CHEMBL4064191 | — | — | 1 | 5.92 |
| CHEMBL4064759 | — | — | 1 | 5.82 |
| CHEMBL4093493 | — | — | 1 | 5.75 |
| CHEMBL4084712 | — | — | 1 | 5.47 |
| CHEMBL4094900 | — | — | 1 | 5.24 |
| CHEMBL4066916 | — | — | 1 | 5.22 |
| CHEMBL4072785 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL4068561 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL4103639 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL4063145 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL4079375 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL4063145 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL4085752 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4068561 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4095881 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL4085752 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4087217 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL4065797 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL4102646 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL4094407 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4092462 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL4064191 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL4064759 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL4093493 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL4084712 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL4094900 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL4066916 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL4072785 | — | Ki | = | 8900.0 | nM | 5.05 |