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Assay Detail

CHEMBL4047015

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of 17-beta estradiol-induced cell proliferation in human MCF7 cells incubated for 6 days by acid red-52 staining based assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Design and synthesis of benzoacridines as estrogenic and anti-estrogenic agents.
Torikai K, Koga R, Liu X, Umehara K, Kitano T, Watanabe K, Oishi T, Noguchi H, Shimohigashi Y.
Bioorg Med Chem (2017) 25 : 5216 -5237
PubMed 28882502 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.33 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL786 TAMOXIFEN CITRATE 4.0 1 6.10
CHEMBL4083736 1 6.02
CHEMBL4071506 1 5.40
CHEMBL4094003 1 5.30
CHEMBL4071813 1 5.04
CHEMBL4066690 1 5.03
CHEMBL4098238 1 5.03
CHEMBL4105062 1 4.71
CHEMBL4085535 1 -
CHEMBL4095701 1 -
CHEMBL4087989 1 -
CHEMBL4104350 1 -
CHEMBL4080114 1 -
CHEMBL4073339 1 -
CHEMBL4092300 1 -
CHEMBL4103461 1 -
CHEMBL4088694 1 -
CHEMBL4067456 1 -
CHEMBL4089627 1 -
CHEMBL4070167 1 -
CHEMBL4071188 1 -
CHEMBL4059814 1 -
CHEMBL4080825 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL786 TAMOXIFEN CITRATE IC50 = 796.0 nM 6.10
CHEMBL4083736 IC50 = 951.0 nM 6.02
CHEMBL4071506 IC50 = 3980.0 nM 5.40
CHEMBL4094003 IC50 = 4950.0 nM 5.30
CHEMBL4071813 IC50 = 9070.0 nM 5.04
CHEMBL4066690 IC50 = 9240.0 nM 5.03
CHEMBL4098238 IC50 = 9240.0 nM 5.03
CHEMBL4105062 IC50 = 19600.0 nM 4.71
CHEMBL4085535 IC50 - -
CHEMBL4095701 IC50 - -
CHEMBL4087989 IC50 - -
CHEMBL4104350 IC50 - -
CHEMBL4080114 IC50 - -
CHEMBL4073339 IC50 - -
CHEMBL4092300 IC50 - -
CHEMBL4103461 IC50 - -
CHEMBL4088694 IC50 - -
CHEMBL4067456 IC50 - -
CHEMBL4089627 IC50 - -
CHEMBL4070167 IC50 - -
CHEMBL4071188 IC50 - -
CHEMBL4059814 IC50 - -
CHEMBL4080825 IC50 - -