Assay Detail
Functional
CHEMBL4047157
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Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
d-Amino acid mutation of PMI as potent dual peptide inhibitors of p53-MDM2/MDMX interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.48 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152332 | — | — | 1 | 5.23 |
| CHEMBL4075572 | — | — | 1 | 4.51 |
| CHEMBL4099164 | — | — | 1 | 4.36 |
| CHEMBL4076935 | — | — | 1 | 4.34 |
| CHEMBL4090785 | — | — | 1 | 4.26 |
| CHEMBL3347578 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152332 | — | IC50 | = | 5930.0 | nM | 5.23 |
| CHEMBL4075572 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL4099164 | — | IC50 | = | 43500.0 | nM | 4.36 |
| CHEMBL4076935 | — | IC50 | = | 45700.0 | nM | 4.34 |
| CHEMBL4090785 | — | IC50 | = | 54300.0 | nM | 4.26 |
| CHEMBL3347578 | — | IC50 | = | 67600.0 | nM | 4.17 |